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Marketing and/or manufacturing authorisation holders are obliged to report to EMA if they detect any (suspected) falsification of a centrally authorised medicine that could pose a risk to public and animal health. For more information and full instructions, see:sudden hearing decrease or hearing loss. Some people may also have ringing in their e
Sildenafil and/or N-desmethylsildenafil, its major active metabolite, may be quantified in plasma, serum, or whole blood to assess pharmacokinetic status in those receiving the drug therapeutically, to confirm the diagnosis in potential poisoning victims, or to assist in the forensic investigation in a case of fatal overdose.[46] Mechanism of actio